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In recent years, the effects of GLP-1 agonists/analogues on the CNS have gained relevance due to emerging evidence supporting the neuroprotective effects of these molecules

Microbial inhibition The 0.9% benzyl alcohol content inhibits the growth of bacteria, fungi, and other microorganisms that could contaminate reconstituted solutions upon repeated vial access

Preclinical studies suggest a synergistic effect between membrane-active agents, stress-pathway inhibitors, and conventional antifungals ( Designing the delivery system should focus on achieving high local concentrations with low systemic exposure factors, such as slow-release catheter coatings or mucoadhesive gels, to fully leverage activity against embedded persisters and minimize toxic effects on the host (Pedro et al., 2023)